数据库系统
切换到图谱视图酶反应数据库检索（支持酶名/底物模糊查询与 kcat、Km 区间筛选；图谱视图仅在命中结果小于 20 条时开放）
记录: 300000
酶: 11
底物: 33
命中: 300000
| Enzyme | Mutation | Substrate | Product | kcat (1/s) | Km (mM) | pH | Temp | DOI | 详情 |
|---|---|---|---|---|---|---|---|---|---|
| CYP71A10 | WT | Chlortoluron | N'-[3-Chloro-4-(hydroxymethyl)phenyl]-N,N-dimethylurea | 0.0116667 | 1000 | - | - | 10.1073/pnas.96.4.1750 |
展开ID：299360
protein_id：O48918
mutations：WT
kcat/Km：1.16667e-05
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Glycine max
wt_sequence
MALLSSVLKQLPHELSSTHYLTVFFCIFLILLQLIRRNKYNLPPSPPKIPIIGNLHQLGTLPHRSFHALSHKYGPLMMLQLGQIPTLVVSSADVAREIIKTHDVVFSNRRQPTAAKIFGYGCKDVAFVYYREEWRQKIKTCKVELMSLKKVRLFHSIRQEVVTELVEAIGEACGSERPCVNLTEMLMAASNDIVSRCVLGRKCDDACGGSGSSSFAALGRKIMRLLSAFSVGDFFPSLGWVDYLTGLIPEMKTTFLAVDAFLDEVIAEHESSNKKNDDFLGILLQLQECGRLDFQLDRDNLKAILVDMIIGGSDTTSTTLEWTFAEFLRNPNTMKKAQEEVRRVVGINSKAVLDENCVNQMNYLKCVVKETLRLHPPLPLLIARETSSSVKLRGYDIPAKTMVFINAWAIQRDPELWDDPEEFIPERFETSQVDLNGQDFQLIPFGIGRRGCPAMSFGLASTEYVLANLLYWFNWNMSESGRILMHNIDMSETNGLTVSKKVPLHLEPEPYKT real_sequence
/ substrate_smiles
CC1=C(C=C(C=C1)NC(=O)N(C)C)Cl product_smiles
C(O)C1=C(C=C(C=C1)NC(=O)N(C)C)Cl raw_row_json
{"enzyme-name": "CYP71A10", "protein-id": "O48918", "wt_sequence": "MALLSSVLKQLPHELSSTHYLTVFFCIFLILLQLIRRNKYNLPPSPPKIPIIGNLHQLGTLPHRSFHALSHKYGPLMMLQLGQIPTLVVSSADVAREIIKTHDVVFSNRRQPTAAKIFGYGCKDVAFVYYREEWRQKIKTCKVELMSLKKVRLFHSIRQEVVTELVEAIGEACGSERPCVNLTEMLMAASNDIVSRCVLGRKCDDACGGSGSSSFAALGRKIMRLLSAFSVGDFFPSLGWVDYLTGLIPEMKTTFLAVDAFLDEVIAEHESSNKKNDDFLGILLQLQECGRLDFQLDRDNLKAILVDMIIGGSDTTSTTLEWTFAEFLRNPNTMKKAQEEVRRVVGINSKAVLDENCVNQMNYLKCVVKETLRLHPPLPLLIARETSSSVKLRGYDIPAKTMVFINAWAIQRDPELWDDPEEFIPERFETSQVDLNGQDFQLIPFGIGRRGCPAMSFGLASTEYVLANLLYWFNWNMSESGRILMHNIDMSETNGLTVSKKVPLHLEPEPYKT", "real_sequence": "/", "mutations": "WT", "Km_mM": 1000.0, "kcat_1s_1": 0.011666667, "Kcat_dev_Km": 1.1666667000000001e-05, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Chlortoluron", "substrate_smiles": "CC1=C(C=C(C=C1)NC(=O)N(C)C)Cl", "product": "N'-[3-Chloro-4-(hydroxymethyl)phenyl]-N,N-dimethylurea", "product_smiles": "C(O)C1=C(C=C(C=C1)NC(=O)N(C)C)Cl", "pH": NaN, "Temp": NaN, "DOI": "10.1073/pnas.96.4.1750", "Source": "Glycine max"}
|
| CYP102A1 | F87A | 12-(4-Nitrophenoxy)dodecanoic acid | 12-hydroxy-(4-Nitrophenoxy)dodecanoic acid | 6.2 | 8100 | 8.2 | 25.0 | 10.1016/s0167-4838(00)00268-5 |
展开ID：299359
protein_id：P14779
mutations：F87A
kcat/Km：0.000765432
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG substrate_smiles
C1=CC(=CC=C1[N+](=O)[O-])OCCCCCCCCCCCC(=O)O product_smiles
C1=CC(=CC=C1[N+](=O)[O-])OC(O)CCCCCCCCCCC(=O)O raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "mutations": "F87A", "Km_mM": 8100.0, "kcat_1s_1": 6.2, "Kcat_dev_Km": 0.0007654320987654322, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "12-(4-Nitrophenoxy)dodecanoic acid", "substrate_smiles": "C1=CC(=CC=C1[N+](=O)[O-])OCCCCCCCCCCCC(=O)O", "product": "12-hydroxy-(4-Nitrophenoxy)dodecanoic acid", "product_smiles": "C1=CC(=CC=C1[N+](=O)[O-])OC(O)CCCCCCCCCCC(=O)O", "pH": 8.2, "Temp": 25.0, "DOI": "10.1016/s0167-4838(00)00268-5", "Source": "Bacillus megaterium"}
|
| CYP2A6 | F209I | coumarin | 7-hydroxycoumarin | 0.833333 | 25000 | 7.4 | 37.0 | 10.1074/jbc.M508171200 |
展开ID：299358
protein_id：P11509
mutations：F209I
kcat/Km：2
Vmax：-
relative_activity：0.408163
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR real_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFIFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR substrate_smiles
C1=CC=C2C(=C1)C=CC(=O)O2 product_smiles
C1=CC(=CC2=C1C=CC(=O)O2)O raw_row_json
{"enzyme-name": "CYP2A6", "protein-id": "P11509", "wt_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "real_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFIFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "mutations": "F209I", "Km_mM": 25000.0, "kcat_1s_1": 0.833333333, "Kcat_dev_Km": 2, "Vmax": NaN, "relative_activity": 0.4081632653061224, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "coumarin", "substrate_smiles": "C1=CC=C2C(=C1)C=CC(=O)O2", "product": "7-hydroxycoumarin", "product_smiles": "C1=CC(=CC2=C1C=CC(=O)O2)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.1074/jbc.M508171200", "Source": "Homo sapiens"}
|
| CYP2C8 | I244V | Arachidonic Acid | 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid | 0.566667 | 7400 | 7.4 | 37.0 | 10.3390/ijms24098032 |
展开ID：299357
protein_id：P10632
mutations：I244V
kcat/Km：4.57
Vmax：-
relative_activity：1.73
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV real_sequence
- substrate_smiles
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O product_smiles
CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O raw_row_json
{"enzyme-name": "CYP2C8", "protein-id": "P10632", "wt_sequence": "MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV", "real_sequence": null, "mutations": "I244V", "Km_mM": 7400.0, "kcat_1s_1": 0.566666667, "Kcat_dev_Km": 4.57, "Vmax": NaN, "relative_activity": 1.73, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Arachidonic Acid", "substrate_smiles": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O", "product": "14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid", "product_smiles": "CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.3390/ijms24098032", "Source": "Homo sapiens"}
|
| CYP1A2 | G437D | 2-amino-3,5-dimethylimidazo(4,5-f)quinoline | 2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline | 0.111667 | 19000 | 7.4 | 37.0 | 10.1021/bi035593f |
展开ID：299356
protein_id：P05177
mutations：G437D
kcat/Km：0.35
Vmax：-
relative_activity：2.91667
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N product_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "G437D", "Km_mM": 19000.0, "kcat_1s_1": 0.111666667, "Kcat_dev_Km": 0.35, "Vmax": NaN, "relative_activity": 2.9166666666666665, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,5-dimethylimidazo(4,5-f)quinoline", "substrate_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N", "product": "2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline", "product_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1021/bi035593f", "Source": "Homo sapiens"}
|
| CYP2C8 | WT | Arachidonic Acid | 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid | 0.585 | 13300 | 7.4 | 37.0 | 10.3390/ijms24098032 |
展开ID：299355
protein_id：P10632
mutations：WT
kcat/Km：2.64
Vmax：-
relative_activity：1
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV real_sequence
/ substrate_smiles
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O product_smiles
CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O raw_row_json
{"enzyme-name": "CYP2C8", "protein-id": "P10632", "wt_sequence": "MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV", "real_sequence": "/", "mutations": "WT", "Km_mM": 13300.0, "kcat_1s_1": 0.585, "Kcat_dev_Km": 2.64, "Vmax": NaN, "relative_activity": 1, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Arachidonic Acid", "substrate_smiles": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O", "product": "14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid", "product_smiles": "CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.3390/ijms24098032", "Source": "Homo sapiens"}
|
| CYP102A1 | F87Y | Lauric acid | 12-Hydroxydodecanoic acid | 27 | 42000 | - | - | 10.1039/c1cs15192d |
展开ID：299354
protein_id：P14779
mutations：F87Y
kcat/Km：0.000642857
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "F87Y", "Km_mM": 42000.0, "kcat_1s_1": 27.0, "Kcat_dev_Km": 0.0006428571428571428, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP2B11 | V183L | Testosterone | 16alpha-Hydroxytestosterone | 0.733333 | 57000 | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299353
protein_id：P24460
mutations：V183L
kcat/Km：0.76
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MELSVLLLLALLTGLLLLMARGHPKAYGHLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGC real_sequence
- substrate_smiles
CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C product_smiles
CC12CCC(=O)C=C1CCC3C2CCC4(C3CC(C4O)O)C raw_row_json
{"enzyme-name": "CYP2B11", "protein-id": "P24460", "wt_sequence": "MELSVLLLLALLTGLLLLMARGHPKAYGHLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGC", "real_sequence": null, "mutations": "V183L", "Km_mM": 57000.0, "kcat_1s_1": 0.733333333, "Kcat_dev_Km": 0.76, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Testosterone", "substrate_smiles": "CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C", "product": "16alpha-Hydroxytestosterone", "product_smiles": "CC12CCC(=O)C=C1CCC3C2CCC4(C3CC(C4O)O)C", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP2D6 | S286T | dextromethorphan | - | 0.00116667 | 12600 | 7.4 | - | 10.1007/s12272-013-0212-5 |
展开ID：299352
protein_id：P10635
mutations：S286T
kcat/Km：0.0056
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR real_sequence
- substrate_smiles
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC product_smiles
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OCO raw_row_json
{"enzyme-name": "CYP2D6", "protein-id": "P10635", "wt_sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR", "real_sequence": null, "mutations": "S286T", "Km_mM": 12600.0, "kcat_1s_1": 0.001166667, "Kcat_dev_Km": 0.0056, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "dextromethorphan", "substrate_smiles": "CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC", "product": null, "product_smiles": "CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OCO", "pH": 7.4, "Temp": NaN, "DOI": "10.1007/s12272-013-0212-5", "Source": "Homo sapiens"}
|
| CYP1A2 | G437D | 2-amino-3,5-dimethylimidazo(4,5-f)quinoline | 2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline | 0.111667 | 19000 | 7.4 | 37.0 | 10.1021/bi035593f |
展开ID：299351
protein_id：P05177
mutations：G437D
kcat/Km：0.35
Vmax：-
relative_activity：2.91667
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N product_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "G437D", "Km_mM": 19000.0, "kcat_1s_1": 0.111666667, "Kcat_dev_Km": 0.35, "Vmax": NaN, "relative_activity": 2.9166666666666665, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,5-dimethylimidazo(4,5-f)quinoline", "substrate_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N", "product": "2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline", "product_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1021/bi035593f", "Source": "Homo sapiens"}
|
| CYP102A1 | I401P | Lauric acid | 12-Hydroxydodecanoic acid | 71 | 21000 | - | - | 10.1039/c1cs15192d |
展开ID：299350
protein_id：P14779
mutations：I401P
kcat/Km：0.00338095
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "I401P", "Km_mM": 21000.0, "kcat_1s_1": 71.0, "Kcat_dev_Km": 0.0033809523809523808, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP2D6 | S286T | Bufuralol | 1'-Hydroxybufuralol | 0.101667 | 5500 | 7.4 | - | 10.1007/s12272-013-0212-5 |
展开ID：299349
protein_id：P10635
mutations：S286T
kcat/Km：1.12
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR real_sequence
- substrate_smiles
CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O product_smiles
CC(C1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O)O raw_row_json
{"enzyme-name": "CYP2D6", "protein-id": "P10635", "wt_sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR", "real_sequence": null, "mutations": "S286T", "Km_mM": 5500.0, "kcat_1s_1": 0.101666667, "Kcat_dev_Km": 1.12, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Bufuralol", "substrate_smiles": "CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O", "product": "1'-Hydroxybufuralol", "product_smiles": "CC(C1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O)O", "pH": 7.4, "Temp": NaN, "DOI": "10.1007/s12272-013-0212-5", "Source": "Homo sapiens"}
|
| CYP105A1 | R73A | 25-hydroxyvitamin D3 | 1-alpha,25-hydroxyvitamin D3 | 0.000333333 | 3600 | 7.4 | 30.0 | 10.1021/bi801222d |
展开ID：299348
protein_id：P18326
mutations：R73A
kcat/Km：0.005
Vmax：-
relative_activity：8
activity_U/mg：-
conversion_rate：-
yield：-
Source：Streptomyces griseolus
wt_sequence
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW real_sequence
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNATDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW substrate_smiles
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C product_smiles
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C raw_row_json
{"enzyme-name": "CYP105A1", "protein-id": "P18326", "wt_sequence": "MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW", "real_sequence": "MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNATDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW", "mutations": "R73A", "Km_mM": 3600.0, "kcat_1s_1": 0.000333333, "Kcat_dev_Km": 0.005, "Vmax": NaN, "relative_activity": 8, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "25-hydroxyvitamin D3", "substrate_smiles": "CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C", "product": "1-alpha,25-hydroxyvitamin D3", "product_smiles": "CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C", "pH": 7.4, "Temp": 30.0, "DOI": "10.1021/bi801222d", "Source": "Streptomyces griseolus "}
|
| CYP102A1 | R47A+Y51F | Lauric acid | 12-Hydroxydodecanoic acid | 35 | 514000 | - | - | 10.1039/c1cs15192d |
展开ID：299347
protein_id：P14779
mutations：R47A+Y51F
kcat/Km：6.80934e-05
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "R47A+Y51F", "Km_mM": 514000.0, "kcat_1s_1": 35.0, "Kcat_dev_Km": 6.809338521400779e-05, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP2D6 | R296C | Bufuralol | 1'-Hydroxybufuralol | 0.015 | 8600 | 7.4 | - | 10.1007/s12272-013-0212-5 |
展开ID：299346
protein_id：P10635
mutations：R296C
kcat/Km：0.1
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR real_sequence
- substrate_smiles
CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O product_smiles
CC(C1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O)O raw_row_json
{"enzyme-name": "CYP2D6", "protein-id": "P10635", "wt_sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR", "real_sequence": null, "mutations": "R296C", "Km_mM": 8600.0, "kcat_1s_1": 0.015, "Kcat_dev_Km": 0.1, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Bufuralol", "substrate_smiles": "CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O", "product": "1'-Hydroxybufuralol", "product_smiles": "CC(C1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O)O", "pH": 7.4, "Temp": NaN, "DOI": "10.1007/s12272-013-0212-5", "Source": "Homo sapiens"}
|
| CYP102A1 | R87A | Lauric acid | 12-Hydroxydodecanoic acid | 25 | 167000 | 8.0 | 27.0 | 10.1021/bi962826c |
展开ID：299345
protein_id：P14779
mutations：R87A
kcat/Km：0.000149701
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "R87A", "Km_mM": 167000.0, "kcat_1s_1": 25.0, "Kcat_dev_Km": 0.0001497005988023952, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": 8.0, "Temp": 27.0, "DOI": "10.1021/bi962826c", "Source": "Bacillus megaterium"}
|
| CYP102A1 | WT | Lauric acid | 12-Hydroxydodecanoic acid | 85 | 280000 | 7.4 | 30.0 | 10.1021/bi049163g |
展开ID：299344
protein_id：P14779
mutations：WT
kcat/Km：0.000303571
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "WT", "Km_mM": 280000.0, "kcat_1s_1": 85.0, "Kcat_dev_Km": 0.00030357142857142855, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": 7.4, "Temp": 30.0, "DOI": "10.1021/bi049163g", "Source": "Bacillus megaterium"}
|
| CYP1A2 | C406Y | 2-amino-3-methylimidazolo(4,5-f)quinoline | 2-Hydroxyamino-3-methylimidazolo(4,5-f)quinoline | 0.138333 | 22000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299343
protein_id：P05177
mutations：C406Y
kcat/Km：0.38
Vmax：-
relative_activity：1.40741
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1N product_smiles
CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "C406Y", "Km_mM": 22000.0, "kcat_1s_1": 0.138333333, "Kcat_dev_Km": 0.38, "Vmax": NaN, "relative_activity": 1.4074074074074074, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3-methylimidazolo(4,5-f)quinoline", "substrate_smiles": "CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1N", "product": "2-Hydroxyamino-3-methylimidazolo(4,5-f)quinoline", "product_smiles": "CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP102A1 | F42A | Lauric acid | 12-Hydroxydodecanoic acid | 41 | 2.08e+06 | - | - | 10.1039/c1cs15192d |
展开ID：299342
protein_id：P14779
mutations：F42A
kcat/Km：1.97115e-05
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "F42A", "Km_mM": 2080000.0, "kcat_1s_1": 41.0, "Kcat_dev_Km": 1.971153846153846e-05, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP102A1 | WT | Palmitic Acid | 15-Hydroxyhexadecanoic acid | 91.4 | 42400 | 7.4 | 30.0 | 10.1002/cbic.201000421 |
展开ID：299341
protein_id：P14779
mutations：WT
kcat/Km：0.00215566
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCCCCCC(=O)O product_smiles
CC(CCCCCCCCCCCCCC(=O)O)O raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "WT", "Km_mM": 42400.0, "kcat_1s_1": 91.4, "Kcat_dev_Km": 0.0021556603773584906, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Palmitic Acid", "substrate_smiles": "CCCCCCCCCCCCCCCC(=O)O", "product": "15-Hydroxyhexadecanoic acid", "product_smiles": "CC(CCCCCCCCCCCCCC(=O)O)O", "pH": 7.4, "Temp": 30.0, "DOI": "10.1002/cbic.201000421", "Source": "Bacillus megaterium"}
|